- PEST
- Dennis, to Mr. Wilson
- Annoying one
- Burr under the saddle
- Insecticide victim
- Nuisance
- Annoying person
- Exterminator's quarry
- Roach or slug
- Roach, for one
- Royal pain
- Kid brother, sometimes
- Pain in the neck
- Terminator's target
- 21A, for one
- Black Flag victim
- Extermination target
- Exterminator's target
- No-see-um, for one
- Troll, e.g.
- Garden scourge
- Persistent pain
- Constant bother
- Nudnik
- Annoyance
- Bug spray target
- Thorn in one's side
- No-see-um, e.g.
- Little bother
- Source of botheration
- Swattable sort
- Source of annoyance
- Younger sib, maybe
- Unwelcome guest
- Unwelcome visitor
- Shoo! addressee
- Real annoyance
- Raid target
- Thorn in the side
- 53 Down, often
- Noodge
- Telemarketer, to many
- Pain
- One who just won't stop
- See 55-Down
- Steve Urkel, to the Winslows, initially
- One may look to get under your skin
- Annoying type
- Black Flag target
- Bug you want to swat
- Buttinsky
- Fumigator's target
- Getting-on-one's-nerves type
- Mosquito or fly
- Pain-in-the-you-know-what
- Exterminator's victim
- Dee Dee, to Dexter on "Dexter's Laboratory"
- Irksome insect
- Aphid, to a gardener
- Unwelcome greenhouse guest
- Babysitter's bane
- Exterminator's assignment
- Mouse, for one
- Thorn
- Dennis the Menace, to Mr. Wilson
- Ant at a picnic, e.g.
- Irritant
- Crop-dusting target
- Heckler, e.g.
- Noodge or nudnik
- Kid brother, at times
- Significant nuisance
- Annoyer
- Mosquito or mole, e.g.
- Irksome sort
- Crop-invading insect
- Orkin agent's quarry
- Fumigation target
- Insect, perhaps
- Bothersome guy
- Animal controlled
- Annoying animal
- Unwanted houseguest
- Harasser
- Nag
- Nudnicks
- Unwelcome child
- Bother
- Botherer
- Bug spray victim
- Heckler
- Imp
- Horticultural woe
- Irksome type
- Little brother, at times
- Pain, so to speak
- Fly, e.g.
- 81-Down, e.g.
- Kid brother, at his worst
- Bothersome kid
- Brat
- Gnat or rat
- Gnat, for one
- Mosquito, e.g.
- 17-Across in the neck
- Orkin target
- Bothersome insect
- Crop threat
- Pantry ant, e.g.
- Recurring pain?
- Garden headache
- Unwanted visitor
- Orkin victim
- Under-one's-skin type
- Unwelcome garden visitor
- Vexatious sort
- Cockroach, e.g.
- Fruit fly or gnat
- Irksome one
- Sitter's challenge
- Unrelenting annoyance
- Yappy dog, e.g.
- Bug or brat
- One told to leave, maybe
- Roach or termite
- 38-Down, e.g.
- Bothersome sort
- Gnat or nag
- Vexation
- Younger sibling, stereotypically
- __ control
- Fungus gnat, e.g.
- Annoying sort
- Gnat or mosquito
- Gnat, e.g.
- Wasp, for one
- Nettlesome one
- Flea, e.g.
- Flea or mosquito
- Mouse, to some
- Nagger
- Mole, to suburbanites
- Fly or roach
- Roach or mole
- 28 Down, for one
- Tiresome one
- Locust, for one
- 10 Across or 49 Across
- Bothersome one
- Genuine nuisance
- Irksome individual
- Gadfly
- Source of exasperation
- Vexatious one
- Fly, perhaps
- Gardening column subject
- Troublesome person
- Teaser
- Irritating one
- Steady annoyance
- Hanger-on
- Irksome person
- Source of vexation
- Vexing one
- Buttonholer
- Arborist's concern
- Persistent inconvenience
- Bothersome person
- Ongoing annoyance
- Fly, for example
- Gnat, for example
- It's across the Danube from Buda
- Sauce whose name is Italian for "pounded"
- Slug, to a gardener
- Housefly, for example
- Nudge
- Applicable to Peck's Bad Boy.
- Victim of D. D. T.
- Town that has been part of Hungary's capital since 1873.
- Varmint.
- Any destructive insect.
- Child with a new drum.
- DDT target.
- Target of DDT.
- Plague.
- Trouble-maker.
- Botheration.
- Bane.
- Half of a European twin city.
- Kibitzer, at times.
- Noxious thing.
- Dennis, for one
- Destructive insect.
- Cause of annoyance.
- Aphid, for instance.
- Mosquito, for one.
- Fly or gnat.
- Mosquito.
- Sticky one
- Unwelcome one
- Fly, for one
- Annoying thing
- Bore
- One to get rid of
- Sheep ked, e.g.
- Gnat or brat
- Kid brother, perhaps
- Lapel grabber
- Mosquito or gnat
- Obnoxious one
- Aphid, to a rose
- Gnat, rat or brat
- Nudnick
- Kid sister to boy of 17
- Aphid, e.g.
- Aphid, for one
- Exterminator's concern
- Gadfly or aphid
- Midge or mosquito
- Lapel clutcher
- Bothersome individual
- Heckler or lapel grabber
- Flea or fly
- Aphid, to a fruit tree
- Midge or aphid
- Pain of a sort
- Weevil, for one
- Buzzy one
- Irk-aholic?
- Adamant ant?
- Cutworm, e.g.
- Hanger-on, maybe
- Termite, e.g.
- 43-Down, e.g.
- Ant, maybe
- Buttinsky, e.g.
- D-Con target
- Little brother, maybe
- Mole, to a gardener
- Persistent annoyer
- Raid victim
- Slug, say
- Younger brother, say
- Mole, e.g.
- Starling, e.g.
- Real pill
- Cockroach or termite
- Dennis the Menace, for one
- With 65-Across, extermination ... or what can be done to 10 answers in this puzzle without affecting their clues?
- One who 26-Across
- Tick, e.g.
- 16-Across, e.g.
- Little brother, to an older sibling, say
- Slug, e.g.
- Fly in the face of someone?
- Garden interloper
- Nag, e.g.
- Real pain
- Trying type
- Rat or roach
- Bedbug, e.g.
- Little sibling, often
- One getting shooed
- Termite or gnat
- Boll weevil, to a cotton farmer
- Little brother, stereotypically
- Little noodge
- Boll weevil, for one
- Persistent little sibling, maybe
- Small headache
- Dennis the Menace, e.g.
- Headache
- Target for an exterminator
- ___ control
- Fly in the face, e.g.
- Irritating sort
- Threat to crops
- Pain in the ass
- Bugging bug
- Irking insect
- It merged with Buda in 1873
- Unloved bug
- Gadfly, e.g.
- Troublesome insect
- Yapping dog, e.g.
- Irksome fellow
- Annoying person or bug
- Bothersome type
- Mosquito, gnat or fly
- Fly or gnat, often
- Bothersome annoyance
- Thing on your nerves
- Aphid or boll weevil
- Ant or mosquito
- Apt rhyme for "infest"
- Flea or tick
- Little sibling, perhaps
- *Cat or goldfish
- Ant in the pantry, e.g.
- Roach or rat
- Weevil, e.g.
- Younger sibling, at times
- Flea or roach
- Importuner for one
- Harrier
- Ant e.g.
- Objectionable one
- One who annoys
- Nosy neighbor
- Paparazzo often
- Bug bomb target
- Pain in the butt
- Brat or bug, e.g.
- Pain in the you-know-what, e.g.
- Kid brother, stereotypically
- Mixed-up PETS?
- Pain in the rear
- Kind of control
- Little brother or spammer, to some
- Mole, to a suburbanite
- 4-Down victim, e.g.
- Black Flag or d-CON target
- Bug bomb victim
- 17-Across or louse
- Ant, to a picnicker
- Mole or mosquito
- 35-Across, to suburbanites
- Fruit fly, to an orchard
- Gnat or brat, for example
- Obnoxious person
- Annoying bug
- Irritating person
- Mosquito, for example
- Termite or ant, for example
- Disease vector
- Aphid or beetle
- Spray victim
- Crop invader
- Harmful insect
- Annoyance like a gnat
- Pantry moth, e.g.
- Spammer, for one
- Little brother, often
- Telemarketer, perhaps
- Kibitzer, e.g.
- Mouse, e.g.
- Robocaller, e.g.
- Mole or mouse
- Little brother, perhaps
- Irritating individual
- Younger sibling, according to an older sibling
