- PAIN
- Agony
- Pesky kid
- Soreness
- Advil target
- No ___, no gain
- Big nuisance
- Gain prerequisite
- Pesky kid, e.g.
- Annoyance
- Obnoxious brat
- World of hurt
- Analgesic's target
- Ache
- Botheration
- Arduous chore
- French bread
- Nuisance
- Ibuprofen target
- Bother
- Couple
- Discomfort
- Reason to take butorphanol
- ___ forces even the innocent to lie: Publilius Syrus
- Pest
- Tylenol's target
- One may be shooting
- Nervy feeling?
- King of ___ ('83 hit for the Police)
- Analgesic target
- Aspirin's target
- Suffering partner?
- Tylenol target
- Reason to take acetaminophen
- Neck ailment?
- Annoying person
- That hurts
- Hurt
- Requisite for gain, so they say
- Suffering's partner, in court
- Major nuisance
- Hassle
- Young brother, often
- Little brother, at times
- Big bother
- Bothersome person
- Pesky one
- Proverbial problem for the neck or butt
- Thorn in one's side
- No ____, no gain
- Tedious type
- Distress
- Torment
- Royal annoyance
- Anguish
- Aleve target
- Partner of suffering
- Royal nuisance
- It can be chronic or shooting
- No __, no gain
- Aspirin target
- See 1-Across
- I feel your __
- What acupuncture relieves, for some
- Royal problem?
- Discomfort cause
- Real hassle
- Annoyance, so to speak
- Major annoyance
- Big hassle
- Hurt feelings?
- Grief
- Cause distress
- Nudnik
- Pesky sort
- Annoying one
- Annoying sort
- Bratty kid
- __ in the neck (pest)
- __ in the neck (annoyance)
- Bothersome task
- Major hassle
- Nuisance, so to speak
- Major inconvenience
- Royal __
- Annoying inconvenience
- Considerable inconvenience
- It "clings cruelly to us," according to Keats
- Stitch, e.g.
- Suffering.
- Twinge.
- Render uneasy.
- Disquiet.
- Misery.
- Neck affliction.
- Neck symptom.
- Unhappy reaction.
- Afflict.
- Charley horse symptom.
- Bread: French.
- Bread: Fr.
- Cause to suffer.
- Bread, in France.
- Sometime neck ailment.
- Trouble.
- Stitch
- Bread, in Bayonne
- Provoke
- ___ in the neck
- Sweet is pleasure after ___: Dryden
- Strong discomfort
- Travail
- What dols measure
- Bread, in Brest
- Ouch's cause
- Our Lady of ___: Swinburne
- Joy's antithesis
- What a French baker produces
- This may stab or shoot
- Troublesome one
- Anodyne's target
- Gagne ___ (French breadwinner)
- Physical suffering
- Ache's cousin
- Aggrieve
- Nice bread
- Excedrin target
- Cause to grimace
- Neuralgia
- What an analgesic stops
- Cause of a wince
- Feeling that makes you say "Ow!"
- Number's target?
- Baby brother, often
- Pill
- Result of punishment
- What lines with stars at the end indicate in comics
- Royal ___
- Something necessary for gain, they say
- It may be unbearable
- Sibling, at times?
- What a dolorimeter measures
- Tough person to tolerate
- Masochist's pleasure
- Pill ... or a reason to take a pill
- Total inconvenience
- Total hassle
- Total headache
- T-___ (noted Auto-Tune user)
- Pestiferous person
- Clinton feels yours
- Bodily distress
- No gain without it
- Clinton felt yours
- Hardly pleasure
- Ouch inducer
- Prerequisite for a weightlifter's gain?
- Emotional distress
- Prerequisite for gain?
- It can follow a fall
- Percocet's target
- Grimace inducer
- It might be in the neck
- Reason for applying a medicated plaster
- Wong To Yick target
- Clubber Lang's prediction for Rocky
- Some athletes play through it
- No ___, no gain (gym saying)
- Unpleasant sensation
- It hurts
- More than discomfort
- No gain? No this
- With 71-Across, Bengay's purpose ... or this puzzle's theme
- It's often evaluated on a :) to :( scale
- Icy Hot target
- What some say is necessary for gain
- Bread for French toast?
- Heating pad target
- What Advil relieves
- Post-marathon sensation, perhaps
- Endorphins producer
- Charley horse, e.g.
- What an analgesic treats
- Cause of grimacing
- Charley horse consequence
- Irksome sort
- Counterpart of pleasure
- Salonpas target
- Reason for using a heating pad
- Reason for using an ice pack
- What Tylenol targets
- What aspirin relieves
- Stitch, sometimes
- Vexation
- Reason for a clinic visit
- Cause of some grimacing
- It might make you smart
- Grimace cause
- Nociceptor's detection
- Wince cause, maybe
