- ORPHAN
- Deprived of parents
- Widow's counterpart, in typesetting
- Harry Potter, e.g.
- One leading a hard-knock life, perhaps
- Annie, for one
- Adjective for rare medical conditions for which it is not commercially viable to produce treatments
- Candidate for adoption
- Parentless child
- Annie of the comics, e.g.
- Annie of the comics, for one
- Dogie, for one
- Little ___ Annie
- Foster child, maybe
- ___ Black (BBC America show featuring multiple clones)
- <<NO CLUE>>
- Annie was one
- Annie, notably
- Dogie, e.g.
- Oliver Twist, e.g.
- Little __ Annie
- Bruce Wayne, e.g.
- Many an adoptee
- Oliver Twist, for one
- Anne of Green Gables or Annie
- Anne of Green Gables, for one
- Annie, e.g.
- Unfunded, as a research project
- Annie Warbucks, formerly
- First line of a paragraph that appears alone at the bottom of a column
- Lacking a commercial sponsor
- Jane Eyre, e.g.
- Oliver Warbucks' "Annie."
- Little Annie, for instance.
- Jane Eyre, for one.
- Deprived one.
- Annie
- Child like Annie
- TV's Webster, for one
- Little Oliver Twist, e.g.
- Deserted animal
- Annie, e.g., in the comics
- Dickens's Pip, e.g.
- Annie or Dondi, of the comics
- Harold Gray's Annie, for one
- Dickens's Oliver Twist or Kipling's Mowgli
- Book printer's no-no
- James of "James and the Giant Peach," for one
- Tom Sawyer or Oliver Twist
- Unmatched sock, informally
- Batman or Harry Potter, e.g.
- Any of the Baudelaire children in "A Series of Unfortunate Events"
- Parentless kid
- Child of war, frequently
- Harry Potter or Anne Shirley, say
- ___ Black (sci-fi series)
- Foundling
- Annie of comics, for one
- Annie or Harry Potter
- Bruce Wayne or Harry Potter, e.g.
- Annie of comics, e.g.
- Comics' Annie, for one
- Harry Potter, for one
- Ward of the state, maybe
