- IRRITANT
- Poison ivy, e.g.
- Poison ivy sap, e.g.
- The pea, to the princess
- Pest
- Pain in the neck
- Fly in the ointment
- Cause of annoyance.
- Agent of annoyance.
- Galling.
- Tear gas, e.g.
- Cigar smoke, to some
- Princess's pea, e.g.
- Pebble in one's shoe, e.g.
- Smoke in one's eyes, say
- Inflammation-causing substance such as pollen
- Cause of a rash
- Grain of sand, to a pearl oyster
- Dripping faucet, perhaps
- Salt on an open wound, for example