Crossword clues for Most painful. 7 letters:PAINFULLike some realizationsPAININGAchyPAINFULSee 17 AcrossPAINFULAgonizingPAINFULSorePAINFULSore, perhapsPAININGAfflictingWIIITISArm pain from playing too much NintendoAGONIESGreat painsTORTURENails-on-blackboard painHEADERSPainful-looking soccer shotsRELIEVEEase, as painDRAGOUTProlong painfullySEARINGIntense, as painSMARTEDWas painfulOTALGIAPain often treated by an ENT doctorDEMEROLPossible prescription for pain palliationSUFFERSFeels the painOPIATESPain medicationsNUTTAPSSome painful flicks, in slangACTEDUPBecame painful againSADISTSYour pain is their gainSCIATICLike some back painBASHFUL*Painfully shyCBDOILSTrendy pain-relieving treatmentsASPIRINPain-relieving pillRUBSRAWAbrades painfullyASPIRINPill for painANODYNEIt relieves painEARACHEPain in a canalGRIMACEPained expressionASPIRINPain pillOTALGIAPain in the earWIIITISElbow pain from playing certain video gamesDEMEROLWith 39-Across, celebrity chef being treated for chronic pain?MYALGICHaving muscle painAFFLICTCause painANBESOLOral pain reliever brandSEARINGPainfully hotEARACHEPainful cold symptomITHURTSPained expression: truth is complicated (2, 5)STOICALBetraying no painSEAWASPJellyfish named for its very painful venomMYALGIAMuscle painTWINGESSudden painsASPIRINPain reliefTAXBITEPain felt in AprilEARACHEBig pain for an elephant?AGONIZEStruggle painfully (over), as a decisionTRAUMASPainful events