Crossword clues for Most hopeful 7 letters:DESPAIRGive up all hopeUSOSHOWHope specialASEPTICLike an in-use operating room, one would hopePLEDOUTSaid one was guilty, hoping for a lighter sentenceDOLORESMrs. HopeMAKEUPSHopes after failuresSTASSENPerennial presidential hopeful HaroldSUITORSBuyout hopefulsTESTFORHope to identify in a labLEARNERStudent, hopefullyALLTHATEverything hoped forSTARLETCertain 17 Across hopefulCLINTONHe hails from HopeAIRPLAYWhat small bands hope forHOTDATEHoped-for Friday night eventONADATEOut with hope of lip-puckering, perhapsUSOTOURWWII excursion for Bob HopeASPIREROne with high hopesGERUNDSWishing and hopingCOSTARSHope and Crosby, oftenCATWALKWhere a Miss America hopeful struts her stuffADORINGLike one's fans, hopefullyLATETAGBase-stealer's hopeMOROCCOHope and Crosby destinationLIMPTONRaising Hope star MarthaDESPAIRGive up hopeRELEASEHoped-for vacation feelingAMILATEHope you haven't startedNEWSNOWSlope hopeUSOTOURHope event, frequently, over a 50-year periodWOULDBEHopefulNOMINEEOscar hopefulKNIEVELHe hoped to miss the last busDIAMONDHope, for oneBURBANKBob Hope Airport cityNOMINEEOscar night hopefulRESTATEMake clearer, hopefullyRAINBOWIllusory hopeDESPAIRLoss of hopeDROPSINWhat a putt does, hopefullyUSOTOURBob Hope venueDESPAIRLose hopeSURGEONSmooth operator, one would hopeAPSCORE4 or 5 is a good one for a coll. hopefulPRAYERSHigh hopes?ASPIRESHopes (to)WASHDAYwhen you wear you WORST clothes (esp if you gotta trek to a laundromat) (and then you just have to hope that you are not destined to have a meet cute at the laundromat bc you are wearing your kelly green high school Field Day tee)STARLETMovie hopefulNICEBOYWhom some parents hope gets brought homeRESCUESOperations documented on the YouTube channel "Hope For Paws"