Crossword clues for It can be a headache 8 letters:HEADACHEAcute problemHEADACHESomething treated by TylenolHEADACHEMajor annoyanceHEADACHESource of worryHEADACHEProblemHEADACHECause of trouble: Colloq.HEADACHEAnnoying situationHEADACHEBig painHEADACHEPain in the butt, ironicallyHEADACHEAnnoyanceHEADACHEAspirin targetHEADACHEMajor inconvenienceHEADACHEPain in the brainHEADACHEBig botherHEADACHEAnnoying person or situationHEADACHEVexatious problemHEADACHEIt's a real pain!HEADACHENuisanceHEADACHEIbuprofen targetHEADACHEInconvenienceHEADACHEOne reason for taking aspirinHEADACHEAny vexing problem: Colloq.HEADACHEBothersome personHEADACHEBothersome typeHEADACHEPain in the buttHEADACHEBig problemTYLENOLSThey help headachesHANGOVERPost-bender headacheASPIRINSHeadache stoppersMIGRAINEHorrible headacheHANGOVERIt can be a headacheDULLPAINSlight headache, maybeOVERBOOKWhat airlines sometimes do, causing headachesNUISANCEHeadacheOHBOTHERSuch a headache!SANDTRAPWoods' headacheMIGRAINEKind of headacheMIGRAINEThrobbing headacheFLATTIREMotorists' headache.MIGRAINENervous headache.STTERESAPatron of headache sufferersMIGRAINEHeadache.BREAKAGEChina-shop headacheMIGRAINESplitting headache.FINANCESCommon causes of headaches.PROTOCOLWashington hostess' headache.LAYOVERSTerminal headaches?FEVERFEWPlant used as an herbal remedy for headachesFEVERFEWPlant used in herbal medicine to treat headachesFLATTIREDriver's headache