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% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)

Crossword clues for It can be a headache 8 letters:

HEADACHE: Acute problem
HEADACHE: Worry
HEADACHE: Any vexing problem: Colloq.
HEADACHE: Bother
HEADACHE: Source of worry
HEADACHE: It's a real pain!
HEADACHE: Major annoyance
HEADACHE: Annoying problem
HEADACHE: Major problem
HEADACHE: Cephalalgia
HEADACHE: Bothersome person
HEADACHE: Big pain
HEADACHE: Pain in the butt, ironically
HEADACHE: Annoyance
HEADACHE: Aspirin target
HEADACHE: Major inconvenience
HEADACHE: Something treated by Tylenol
HEADACHE: Inconvenience
HEADACHE: Vexatious problem
HEADACHE: One reason for taking aspirin
HEADACHE: Nuisance
HEADACHE: Pain in the brain
HEADACHE: Cause of trouble: Colloq.
HEADACHE: Problem
HEADACHE: Annoying situation
HEADACHE: Ibuprofen target
HEADACHE: Big bother
HEADACHE: Bothersome type
HEADACHE: Pain in the butt
HEADACHE: Big problem
HANGOVER: It can be a headache
MIGRAINE: Horrible headache
OVERBOOK: What airlines sometimes do, causing headaches
OHBOTHER: Such a headache!
DULLPAIN: Slight headache, maybe
NUISANCE: Headache
LAYOVERS: Terminal headaches?
FEVERFEW: Plant used as an herbal remedy for headaches
HANGOVER: Post-bender headache
SANDTRAP: Woods' headache
MIGRAINE: Kind of headache
FLATTIRE: Motorists' headache.
MIGRAINE: Nervous headache.
STTERESA: Patron of headache sufferers
MIGRAINE: Headache.
BREAKAGE: China-shop headache
MIGRAINE: Splitting headache.
FINANCES: Common causes of headaches.
PROTOCOL: Washington hostess' headache.
FEVERFEW: Plant used in herbal medicine to treat headaches