Crossword clues for Historically significant 7 letters:FATEFULHistorically significantEPOCHALHistorically significantERAHistorically significant periodERASThey're historically significantATESTHistorically significant trialTHEFIRSTMAJORMEMORIALTOWith 105-Across, historical significance of the 122-/124-AcrossERASignificant historical spanCOCOBUTTERAInformal term for the period of time when comedian O'Brien had a historically significant bottom?ERASHistorically significant periodsERASPeriods of historical significancePERIODPIECEItem of historical significanceERASignificant time, historicallyERASignificant time span, historically