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% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)

Crossword clues for Great misfortune. 11 letters:

CATASTROPHE: Great misfortune.
WOE: Great misfortune
SMA: He'll hae misfortunes great an' __: Burns
CALAMITY: Great misfortune
DISASTER: Great misfortune