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% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)

Crossword clues for Do your darnedest 3 letters:

TRY: Do one's darnedest
TRY: Do your darnedest
DARNEDEST: Utmost
DARNEDEST: Utmost, informally
OHGEE: Ain't that the darnedest!
ENDEAVOR: Do one's darnedest