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% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)

Crossword clues for Cartoonists' creations, once:

CELS: Cartoonists' creations, once
COMIC: Cartoonist's creation
CATHY: Cartoonist Guisewite's creation
COLOLBLIMP: Creation of British cartoonist David Low