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% replaces any number of letters (la% - lake, lamp)_ replaces one letter (ca_ - car, cat)

Crossword clues for 5-Down's opposite:

ANTI: 5-Down opposite
AYE: Opposite of 5-Down
ABE: Figure opposite Marian, Eleanor, and Martin, on the new $5 bill
ABOVE: Opposite of 5 Across
ARE: 5-Down's opposite